Why the study?
Does cardiac-directed expression of ACVI increase responsiveness to catecholamine stimulation in transgenic mice?
Does cardiac-directed expression of ACVI increase responsiveness to catecholamine stimulation in transgenic mice?
Overexpressing adenylylcyclase VI in the heart safely increases cardiac responsiveness to beta-adrenergic stimulation without causing detrimental continuous activation.
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Suggests ACVI overexpression as a targeted strategy to enhance beta-adrenergic responsiveness without toxicity; leaves open translation to human heart failure therapies.
Gao et al. (1999) studied this question.
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