Key result
The 96-well Optimul assay showed 82% concordance with light transmission aggregometry (κ = 0.62, P < .0001) and demonstrated high sensitivity (94%) for detecting mild platelet defects.
Why the study?
Does the Optimul assay accurately characterize platelet defects compared to light transmission aggregometry in patients with bleeding and healthy volunteers?
Population
125 individuals, comprising healthy volunteers, healthy volunteers treated with antiplatelet agents in…
Comparison
Optimul, a 96-well plate-based assay of 7… vs Light transmission aggregometry (LTA)
Design
Cross-sectional
Authors
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May support Optimul as high-throughput screen for mild platelet defects; leaves open prospective validation before clinical adoption.
Observational (n=125)
Does the Optimul assay accurately characterize platelet defects compared to light transmission aggregometry in patients with bleeding and healthy volunteers?
Effect estimate: κ = 0.62
p-value: p=<.0001
The Optimul assay is a sensitive, high-throughput screening option for detecting mild platelet defects in patients with bleeding symptoms, performing comparably to or better than LTA.
Lordkipanidzé et al. (2014) conducted an observational in Bleeding of unknown origin (n=125). Optimul assay vs. Light transmission aggregometry (LTA) was evaluated on Concordance between Optimul and LTA assays (κ = 0.62, p=<.0001). The 96-well Optimul assay showed 82% concordance with light transmission aggregometry (κ = 0.62, P < .0001) and demonstrated high sensitivity (94%) for detecting mild platelet defects.
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