Key result
An 80-year-old woman developed fatal amiodarone-induced liver injury and early cirrhosis that uniquely lacked the classic histologic features of steatosis and phospholipidosis.
Case Report (n=1)
No
Amiodarone can induce acute and chronic liver injury leading to early cirrhosis even in the absence of typical histopathological findings like steatosis and phospholipidosis.
Amiodarone hepatotoxicity may occur without steatosis or phospholipidosis; single case leaves open need for expanded diagnostic criteria.
We present a case report of an 80-year-old woman with volume overload thought initially to be secondary to heart failure, but determined to be amiodarone-induced acute and chronic liver injury leading to submassive necrosis and bridging fibrosis consistent with early cirrhosis. Her histopathology was uniquely absent of steatosis and phospholipidosis, which are commonly seen in AIC.
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Buggey et al. (2015) conducted a case report in Amiodarone-induced liver injury and cirrhosis (n=1). Amiodarone was evaluated. An 80-year-old woman developed fatal amiodarone-induced liver injury and early cirrhosis that uniquely lacked the classic histologic features of steatosis and phospholipidosis.
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