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Whole body autoradio‐grams of mice injected intravenously with (‐)‐nicotine‐methyl‐C 14 show an initial accumulation of radioactivity in the CNS. This high concentration of nicotine and/or its metabolites in the brain disappears within 30 min to 1 hour. Autoradio‐grams of cat brain show a similar accumulation of radioactivity following i. v. injection of C 14 ‐nicotine. The distribution picture changes with time after injection. Only one metabolite, viz. cotinine, has been found to occur in the brains of mice and cats. The possible existence of nicotine receptors in the brain is discussed.
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Appelgren et al. (1962) studied this question.
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