Key result
A 42-year-old female presenting with interstitial lung disease was diagnosed with primary pulmonary intravascular large B-cell lymphoma via biopsy and died 20 months later after refusing chemotherapy.
Case Report (n=1)
No
Primary pulmonary intravascular large B-cell lymphoma is an extremely rare condition that can mimic interstitial lung disease and requires surgical biopsy for definitive diagnosis.
Alerts clinicians to rare lymphoma mimics in ILD; case report leaves open optimal diagnostic strategies.
OBJECTIVE: To investigate the clinicopathological features of primary intravascular large B-cell lymphoma of lung. METHODS: A case of primary pulmonary intravascular large B-cell lymphoma was analysed in histopathology and immunophenotype. RESULTS: The patient is a 42-year-old female who had cough for one year. Computed tomography showed ground-glass opacities and small nodules in bilateral lung fields. Histopathology demonstrated accumulation of similar sized neoplastic cells within alveolar capillaries, widening the alveolar septae. The alveolar structure sustained in part of districtions. Immunohistologically, the tumor cells were positive for CD20 and negative for CD3,CK, which were similar to the diffuse large B-cell lymphoma. CONCLUSIONS: Intravascular large B-cell lymphoma is an uncommon type of non-Hodgkin's lymphoma. Primary pulmonary presentation is even more rare. The diagnosis is based on the histopathology and immunohistochemistry. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2076991810705433.
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Yu et al. (2012) conducted a case report in Primary Intravascular large B-cell lymphoma of lung (n=1). Pulmonary biopsy was evaluated. A 42-year-old female presenting with interstitial lung disease was diagnosed with primary pulmonary intravascular large B-cell lymphoma via biopsy and died 20 months later after refusing chemotherapy.
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