Glaucoma: Macrocosm to Microcosm The Friedenwald Lecture

internship, he spent 1 year studying ophthalmic pathology with Fredrich Verhoeff (Harvard), had a 1-year preceptorship with George de Schweinitz (Philadelphia), and then began practice without further training. He seemed not to need it. He was in charge of “Ophthalmic Pathology,...and directed the lion’s share of research activities of the Wilmer Institute” from 1923 to his death in 1955. 1(p24) He excelled at the correlation of clinical and pathologic findings, as continued by A. Edward Maumenee and W. Richard Green at Wilmer after him. He was described as a “many faceted genius, ” accomplished in physics, mathematics, chemistry, and ophthalmology. In his 1949 Proctor Lecture, 2 he summarized evidence that the formation of aqueous humor was an energy-dependent, enzymedriven process. These ideas led to the development of carbonic anhydrase inhibitors for glaucoma treatment. He placed the