Key result
The integrated genetic-epigenetic model Epi+Gen CHD significantly predicted 3-year risk for incident coronary heart disease (HR 3.14) and demonstrated higher sensitivity than standard risk calculators.
Why the study?
The Framingham Risk Score and ASCVD Pooled Cohort Equation perform poorly for predicting risk of incident CHD.
Does an integrated genetic-epigenetic model improve the prediction of 3-year incident coronary heart disease compared to FRS and PCE?
Cohort (n=2,078)
Yes
Does an integrated genetic-epigenetic model improve the prediction of 3-year incident coronary heart disease compared to FRS and PCE?
A novel integrated genetic-epigenetic model demonstrated higher sensitivity for predicting 3-year incident coronary heart disease compared to traditional FRS and PCE risk scores.
Answers are grounded in this paper and cite their sources.
May aid CHD risk stratification; hypothesis-generating for clinical adoption pending prospective validation.
Aim: The Framingham Risk Score (FRS) and atherosclerotic cardiovascular disease (ASCVD) Pooled Cohort Equation (PCE) for predicting risk for incident coronary heart disease (CHD) work poorly. To improve risk stratification for CHD, we developed a novel integrated genetic-epigenetic tool. Materials & methods: Using machine learning techniques and datasets from the Framingham Heart Study (FHS) and Intermountain Healthcare (IM), we developed and validated an integrated genetic-epigenetic model for predicting 3-year incident CHD. Results: Our approach was more sensitive than FRS and PCE and had high generalizability across cohorts. It performed with sensitivity/specificity of 79/75% in the FHS test set and 75/72% in the IM set. The sensitivity/specificity was 15/93% in FHS and 31/89% in IM for FRS, and sensitivity/specificity was 41/74% in FHS and 69/55% in IM for PCE. Conclusion: The use of our tool in a clinical setting could better identify patients at high risk for a heart attack.
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Dogan et al. (2021) conducted a cohort in Incident coronary heart disease (n=2,078). Epi+Gen CHD model vs. Framingham Risk Score and Pooled Cohort Equation was evaluated on 3-year incident coronary heart disease (HR 3.14, 95% CI 2.33-4.23, p=<0.005). The integrated genetic-epigenetic model Epi+Gen CHD significantly predicted 3-year risk for incident coronary heart disease (HR 3.14) and demonstrated higher sensitivity than standard risk calculators.
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