In clinical practice, patients are encountered who are partial responders or nonresponders to clozapine. There are others who are unable to tolerate a high dosage of clozapine. In the two cases presented, we propose an alternative strategy using olanzapine in combination with clozapine in treatment-refractory patients. Olanzapine was found to be helpful in these patients, however, controlled studies are needed.
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Gupta et al. (1998) studied this question.