Fertility Preservation and Spontaneous Pregnancy in a Young Woman with Sertoli-Leydig Cell Tumor: A Five-Year Disease-Free Case Report

Wen-Qiang Hu,1 Yan-Yan Fan2 1Department of Obstetrics and Gynecology, Gansu Provincial Maternal and Child Health Care Hospital, Lanzhou, 730050, People’s Republic of China; 2Department of Obstetrics and Gynecology, The First Hospital of Jilin University, Changchun, 130021, People’s Republic of ChinaCorrespondence: Yan-Yan Fan, Department of Obstetrics and Gynecology, The First Hospital of Jilin University, No. 71 Xinmin Street, Chaoyang District, Changchun, 130021, People’s Republic of China, Tel +86 13756127961, Email fanyanyanfyy01@126.comBackground: Sertoli–Leydig cell tumors (SLCTs) are uncommon ovarian sex cord-stromal neoplasms that predominantly affect young women and are frequently associated with hyperandrogenic features.Case Description: A 23-year-old nulliparous woman presented with a left ovarian mass, accompanied by amenorrhea, clinical signs of virilization, and significantly elevated α-fetoprotein levels. Surgical intervention via left salpingo-oophorectomy was performed. Histopathological evaluation confirmed a Stage IA moderately to poorly differentiated SLCT. Postoperative management included adjuvant chemotherapy with the etoposide and cisplatin, along with administration of a gonadotropin-releasing hormone agonist as an adjunctive measure. No evidence of tumor recurrence was observed over a five-year surveillance period. Subsequently, the patient achieved a spontaneous pregnancy and delivered a healthy male neonate via vaginal delivery.Conclusion: This case demonstrates that in young women with stage IA SLCT, fertility-sparing surgery combined with adjuvant chemotherapy and ovarian preservation strategies may be considered feasible in selected patients for five-year disease-free survival and subsequent spontaneous pregnancy.