A 6-bp deletion in exon 8 of the TYRP1 gene underlies brown coat colour development in Zhaotong pigs

Chunlu Zhou; Xinpeng Li; Wenjun Dong; Lixing Wang; Jinyu Chu; Yuqing Chong; Yunlong Ma; Xinxing Dong; Dawei Yan

doi:10.1016/j.ygeno.2026.111265

May 1, 2026GenomicsOpen Access

A 6-bp deletion in exon 8 of the TYRP1 gene underlies brown coat colour development in Zhaotong pigs

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Key Points

To identify the genetic basis for the brown coat color in Zhaotong pigs.
Analysis of the TYRP1 gene and its variation in Zhaotong pigs.
Identification of a specific 6-bp deletion in exon 8 of TYRP1.
The 6-bp deletion in TYRP1 reduces eumelanin synthesis, leading to the brown coat color in Zhaotong pigs.
Functional assessment confirms the role of TYRP1 in melanin production.

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Implication

Genetic analysis reveals a deletion affecting coat color in Zhaotong pigs, suggesting new breed-specific traits.

Abstract

• Zhaotong pigs (ZTs) have a unique genetic background distinct from other breeds. • TYRP 1 and NFIB are important functional genes influencing brown coat colour in ZTs. • A 6-bp deletion in TYRP 1 reduces eumelanin synthesis, causing brown coat in ZTs.

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Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/6a17daf83fad632b0f9d7d57 https://doi.org/10.1016/j.ygeno.2026.111265

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A 6-bp deletion in exon 8 of the TYRP1 gene underlies brown coat colour development in Zhaotong pigs

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

A 6-bp deletion in exon 8 of the TYRP1 gene underlies brown coat colour development in Zhaotong pigs

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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