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Research demonstrates how amyloid-β affects contractility in human brain vascular smooth muscle cells, suggesting implications for vascular injury in CAA and AD.
• Aβ deposition was visualized on human brain vascular smooth muscle cells using quantum dot-based imaging methods. • Aβ deposition on vascular smooth muscle cells resulted disorganizations of cytoskeleton and loss of the contractile function. • These findings provide mechanistic insight into vascular injury in CAA and AD.
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Kobayashi et al. (2026) studied this question.
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