Key result
Sickle cell anemia links to ~7 mmHg lower diastolic blood pressure and decreased ACE activity.
Why the study?
SCD patients tend to present with relatively lower systemic blood pressure via an unknown mechanism despite vascular dysfunction.
Does enalapril modulate blood pressure and renin-angiotensin-system components in a murine model of sickle cell disease?
Population
Human subjects and mice with and without SCD
Comparison
Enalapril (25 mg/kg, 5x/week) vs untreated controls in mice
Design
Comparative human observational and preclinical animal interventional study
Follow-up
5 weeks
Authors
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Relative hypotension in sickle cell disease may relate to reduced ACE activity; murine findings leave open ACE inhibitor effects on blood pressure.
Cross-Sectional (n=98)
Yes
Does enalapril modulate blood pressure and renin-angiotensin-system components in a murine model of sickle cell disease?
Absolute Event Rate: 68.1% vs 74.9%
p-value: p=<0.05
In a murine model of sickle cell disease, relative hypotension is associated with decreased ACE concentrations, and ACE inhibition with enalapril does not further reduce blood pressure.
Brito et al. (2022) conducted a cross-sectional in Sickle cell disease (n=98). None vs. Healthy controls was evaluated on Diastolic blood pressure (mmHg) (p=<0.05). Patients with sickle cell anemia had significantly lower diastolic blood pressure compared to healthy controls (68.1 vs 74.9 mmHg), associated with decreased plasma ACE concentrations and activity.