Ruthenium( ii )/diphosphine/naphthoquinone complexes: synthesis, characterization, anticancer activity and molecular docking studies

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Ru(ii)-naphthoquinone complexes exhibit effective anticancer activity against human triple-negative breast cancer cells (MDA-MB-231) by inducing ROS-mediated apoptosis. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Analu R. Costa; Leticia Pires de Oliveira; Marcos V. Palmeira‐Mello; João Honorato de Araujo-Neto; Mauro A. Lima; Carlos André Moraes; Renan Lira de Farias; Felipe C. Demidoff; Chaquip D. Neto; Márcia R. Cominetti; Matheus Reis Santos de Melo; Heloiza Diniz Nicolella; S. Abe; Elisânia Kelly Barbosa Fonseca; Marco Aurélio Zezzi Arruda; Javier Ellena; Denise Crispim Tavares; Fillipe V. Rocha; Alzir A. Batista

doi:10.1039/d6dt00204h

Key Points

The study aims to evaluate the anticancer activity of ruthenium(II)-naphthoquinone complexes against triple-negative breast cancer.
Synthesis and characterization of Ru(II)-naphthoquinone complexes.
Flow cytometry and western blotting utilized to assess mechanisms of action.
Assessment focused on the induction of apoptosis through reactive oxygen species.
Ruthenium(II)-naphthoquinone complexes demonstrated significant anticancer activity against MDA-MB-231 cells.
Mechanism of action confirmed as apoptosis induced by increased levels of reactive oxygen species.
Data indicate enhanced cell death in treated cancer cells compared to controls.

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Implication

Investigates anticancer activity of Ru(II) complexes in triple-negative breast cancer, suggesting effective treatment potential.

Abstract

Ru( ii )-naphthoquinone complexes are effective against human triple-negative breast cancer (MDA-MB-231). Flow cytometry and western blotting confirmed the mechanism of action via apoptosis induced by reactive oxygen species (ROS).

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Cite This Study

Costa et al. (2026) studied this question.

synapsesocial.com/papers/6a17dc453fad632b0f9d8f42 https://doi.org/10.1039/d6dt00204h

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Ruthenium( ii )/diphosphine/naphthoquinone complexes: synthesis, characterization, anticancer activity and molecular docking studies

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Cite This Study

Ruthenium( ii )/diphosphine/naphthoquinone complexes: synthesis, characterization, anticancer activity and molecular docking studies

Key Points

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Implication

Abstract

Discussion

Cite This Study

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