Formulation & Evaluation of Indomethacin-Loaded Hydrogel Bandages for Wound Healing

The present study focuses on the formulation and evaluation of an indomethacin-loaded hydrogel film for transdermal drug delivery. Indomethacin, a non-steroidal anti-inflammatory drug, was incorporated into a polymeric matrix composed of polyvinyl alcohol (PVA) and hydroxypropyl methylcellulose (HPMC) using the solvent casting method. PEG 400 was used as a solvent for drug incorporation, while glycerin acted as a plasticizer and propyl paraben as a preservative. The prepared hydrogel film was evaluated for various physicochemical parameters including physical appearance, thickness, weight variation, surface pH, drug content uniformity, and in-vitro drug release. The film was found to be transparent, smooth, and uniform in appearance, with an average thickness of 1.5 mm and consistent weight distribution. The surface pH (6.82) indicated good compatibility with skin, minimizing the risk of irritation. Drug content analysis showed uniform distribution of indomethacin within the film, with a linear calibration curve confirming analytical accuracy. In-vitro dissolution studies revealed a sustained and controlled drug release profile over 60 minutes, demonstrating effective drug diffusion from the polymer matrix. Overall, the formulated hydrogel film exhibited desirable characteristics for transdermal application and can be considered a promising alternative for controlled delivery of indomethacin.