Key result
Sepsis from infectious mediastinitis linked to rare Takotsubo cardiomyopathy in an infant post-VSD repair.
Why the study?
Takotsubo syndrome is a rare cause of ventricular dysfunction in children, and sepsis is rarely identified as the triggering stress factor in infants following cardiac surgery.
Case Report (n=1)
Highlights that sepsis can be a rare triggering factor for Takotsubo syndrome in infants following cardiac surgery.
Answers are grounded in this paper and cite their sources.
Postoperative infection may trigger Takotsubo cardiomyopathy in infants; extends known triggers and leaves open need for prospective validation.
Takotsubo syndrome (TTS) is a rare cause of ventricular dysfunction in children, commonly associated with neurological injury and emotional stress. After cardiac surgery, ventricular dysfunction may result from cardiopulmonary bypass-related myocardial stunning; however, other causes, including TTS, may develop days or weeks after surgical procedures. Stress factors can have multiple etiologies; rarely, sepsis is the triggering factor in infants following cardiac surgery. We present the case of a 5-month-old girl who, 2 weeks after ventricular septal defect repair, developed infectious mediastinitis secondary to a deep surgical site infection, with echocardiographic findings consistent with Takotsubo cardiomyopathy.
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Rubio-Duarte et al. (2026) conducted a case report in Takotsubo cardiomyopathy (n=1). A 5-month-old girl developed Takotsubo cardiomyopathy triggered by infectious mediastinitis 2 weeks after ventricular septal defect repair, highlighting sepsis as a rare trigger in infants.
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