Novel (+)-usnic acid derivatives, computational studies and biological evaluation as neuroprotective agents

AIMS: This study involves the semi-synthetic modification of (+)-usnic acid and the evaluation of the synthesized compounds for neuroprotective effects in scopolamine-injured C6 glial cells. MATERIALS AND METHODS: studies were conducted to predict drug-likeness and binding sites for these molecules. RESULTS: studies confirmed that these compounds decreased NO production by binding to neuronal nitric oxide synthase. CONCLUSION: Usnic acid and its derivatives, 6, 13, and 16, increased the survival of scopolamine-injured C6 glial cells.