Formulation and Evaluation of Fast Release Oral Patches Containing Chlorhexidine

The present study focused on the formulation and evaluation of fast-dissolving mucoadhesive buccal films of chlorhexidine for the effective management of oral infections. The films were prepared using suitable polymers and excipients selected based on their film-forming and mucoadhesive properties, employing the solvent casting method under controlled conditions. Various formulations were developed by optimizing polymer and plasticizer concentrations to achieve films with desirable physicochemical characteristics. The optimized formulation exhibited uniform thickness, flexibility, and stability, indicating the reliability of the preparation method. The buccal films demonstrated rapid drug release along with effective mucoadhesion, ensuring prolonged residence time in the oral cavity. This approach successfully addressed the limitation of rapid drug clearance commonly associated with conventional oral dosage forms. Overall, the developed buccal film system showed improved drug availability, enhanced retention, and better patient compliance, highlighting its potential as an efficient and patient-friendly alternative for the treatment of oral infections.