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January 1, 2026RSC AdvancesOpen Access

From molecular design to antiepileptic evaluation: sulfonamide–pyrazole derivatives as promising neuroactive agents

Mohamed K. Elgohary Mahmoud Abdelrahman Alkabbani Aya Mohamed Ahmed Ibrahim Ahmed Elsonbaty Abdelhameed Abubakr Mayada Mohamed Abdulrahman A. Almehizia Ahmed M. Naglah Mohamed Fares Hatem A. Abdel-Aziz

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Key Points

The aim is to evaluate the efficacy of sulfonamide–pyrazole derivatives as neuroactive agents in addressing mechanisms of epilepsy.
Developed sulfonamide–pyrazole derivatives targeting neuroinflammatory pathways.
Assessed the impact of these compounds on oxidative stress and excitotoxic mechanisms in preclinical models.
Demonstrated significant reduction in neuroinflammation markers in treated models.
Showed decreased oxidative stress levels and excitotoxicity related to glutamate exposure.

Implication

Experimental evaluation of sulfonamide–pyrazole derivatives targets neuroinflammation in epilepsy, suggesting potential therapeutic benefits.

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Cite This Study

Elgohary et al. (2026) studied this question.

synapsesocial.com/papers/6a17dd313fad632b0f9d9dba https://doi.org/10.1039/d6ra01165a

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