Assessment of quality of life of patients with primary hypothyroidism treated with levothyroxine in Jeddah: A cross-sectional study

Context: Hypothyroidism is a persistent condition caused by inadequate production of thyroid hormones. Women are more likely to develop hypothyroidism than men. The most frequently prescribed drug for hypothyroidism is levothyroxine, which raises thyroxine hormone levels and lowers thyroid-stimulating hormone levels. Aims: This study aimed to assess the quality of life (QoL) of patients with hypothyroidism treated with levothyroxine by evaluating clinically relevant determinants using the 12-item Short Form Survey. Settings and Design: This cross-sectional study was conducted at the Endocrine Clinic of King Abdulaziz University Hospital. Materials and Methods: To ensure effective compliance, systematic follow-up consisting of nurse-led telephone follow-ups and patient education was performed, which significantly improved medication adherence in patients with chronic diseases. Statistical Analysis Used: For statistical analysis, this study used multivariate logistic regression analysis to evaluate the risk variables for low QoL. Results: Among the 92 participants, the mean age was 46.03 ± 12.35 years, and 91.3% were female. Half of the patients (50%) had poor QoL, with 52.2% showing poor physical health and 51.1% poor mental health. No significant associations were found between QoL and demographic or clinical characteristics. However, lack of regular follow-up with healthcare providers was significantly associated with poor QoL (odds ratio: 4.45 [1.1–19.59], P = 0.048). Conclusions: The absence of regular follow-up with healthcare providers is a significant risk factor for diminished QoL.