Organocatalytic synthesis demonstrates improved enantioselectivity in dihydroquinoline and hydantoin hybrids, indicating new synthetic pathways.
Herein, an organocatalytic asymmetric synthesis of dihydroquinoline/hydantoin hybrids is described. The synthetic protocol involves a tandem reaction comprising a phosphoric acid–catalyzed initial Povarov dimerization of in situ generated imine/enamine mixtures under tautomeric equilibrium, followed by a Urech–Read reaction of the 1,2‐dihydroquinoline intermediates, which are amino acid derivatives.
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Serna-Burgos et al. (2026) studied this question.
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