Poor antisaccade performance correctly identified 70% of schizophrenia patients and 25-50% of their nonpsychotic first-degree relatives, yielding risk ratios of 20:1 to 50:1 for family liability.
Observational (n=365)
Sí
Does poor antisaccade performance identify liability for schizophrenia in family samples?
Poor antisaccade performance is a promising indicator of liability for schizophrenia, identifying a high proportion of patients and their unaffected first-degree relatives.
Estimación del efecto: RR 20 to 50
The ability to identify unaffected gene carriers within families may be crucial to the success of schizophrenia genetics studies. Data collected from three family samples ( N = 365) demonstrated that poor antisaccade performance is an exceptionally promising indicator of liability for schizophrenia. A particular antisaccade task version provides large separations (5–6 sigma) between proband and normal groups. Poor antisaccade performance alone correctly identified 70% of patients in California, Utah, and Micronesia schizophrenia samples. Twenty‐five to 50% of these patients' nonpsychotic first‐degree relatives also had poor antisaccade performance, yielding risk ratios around 20:1 for simplex and 50:1 for multiplex schizophrenia families. Poor antisaccade performance is associated with dorsolateral prefrontal cortex pathology, suggesting that dysfunction of this circuitry also may predispose individuals to developing this disease.
McDowell et al. (Fri,) conducted a observational in Schizophrenia (n=365). Antisaccade task vs. Normal groups was evaluated on Identification of schizophrenia patients and liability in relatives (RR 20 to 50). Poor antisaccade performance correctly identified 70% of schizophrenia patients and 25-50% of their nonpsychotic first-degree relatives, yielding risk ratios of 20:1 to 50:1 for family liability.
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