The Physiological Significance of the Secretion of Endogenous Insulin Into the Portal Circulation. Iv. Hepatic Uptake of Glucose During Glucose Infusion in Non-Diabetic Dogs*

Recent studies from this laboratory (1) have shown that insulin has an immediate and pro- found effect upon net hepatic glucose balance. When insulin was administered at a rate (2) es- timated to minimize the counter-regulatory re- sponses to hypoglycemia, the decline in blood glu- cose which ensued was largely the consequence of a diminished hepatic release of glucose (1).