Plasma PLA2 activity in patients with uncomplicated acute myocardial infarction increased significantly on days 2-4 to 1.94 nmol/min per mL compared to 1.52 nmol/min per mL in normal males (P<0.001).
Observational (n=27)
Plasma PLA2 activity increases significantly 2-4 days after acute myocardial infarction and correlates with peak CK levels, likely reflecting release from damaged myocardium.
Absolute Event Rate: 1.94% vs 1.52%
p-value: p=<0.001
Phospholipase A2 (PLA2) cleaves phospholipids to produce a lyso-phospholipid and free fatty acid and, in view of the biological activity of the products, PLA2 may play a role in many disease states. Lyso-phospholipids and free arachidonic acid increase in ischaemic myocardium, indicating that ischaemia activates the enzyme. 2. Plasma PLA2 activity was measured in patients with acute myocardial infarction, based on the release of labelled arachidonic acid from Escherichia coli cell membrane. Fourteen males (peak serum creatine phosphokinase (CK) above twice upper normal) were studied on day 1 (within 6 h of chest pain onset), days 2-4, and days 6-9. Normal age matched males (n = 13) were also studied. 3. Plasma PLA2 in patients with uncomplicated myocardial infarction (n = 12) was, initially, 1.14 +/- 0.10 (s.e.m.) nmol/min per mL plasma, similar to that in the normal group (1.52 +/- 0.14). On days 2-4, PLA2 activity increased to 1.94 +/- 0.18 (P less than 0.001) and this activity was correlated with the earlier peak CK level (P less than 0.02). On days 6-9, PLA2 activity was 1.49 +/- 0.13 while in two patients who developed complications and underwent open-heart surgery between the last two measurements, there were further increases to 4.22 and 4.04 nmol/min per mL. 4. The increase in plasma PLA2 in uncomplicated myocardial infarction is likely to be due to release from the damaged myocardium; whether it contributes to pathophysiology is uncertain.
Leong et al. (Sat,) conducted a observational in Acute myocardial infarction (n=27). Plasma PLA2 activity measurement vs. Normal age-matched males was evaluated on Plasma PLA2 activity on days 2-4 (p=<0.001). Plasma PLA2 activity in patients with uncomplicated acute myocardial infarction increased significantly on days 2-4 to 1.94 nmol/min per mL compared to 1.52 nmol/min per mL in normal males (P<0.001).