Number and type of TET2 mutations in chronic myelomonocytic leukemia and their clinical relevance

TET2, located on chromosome 4q24, is frequently mutated (~60%) in patients with chronic myelomonocytic leukemia (CMML). 1,2 TET2 has 11 exons, and variations, especially in exon 3 have been described as a part of age-related clonal hematopoiesis. and all-cause mortality (HR-3.7). The exact mechanism behind this interaction remains to be elucidated, one potential explanation being better responses to hypomethylating agents. In the current larger CMML patient cohort (n = 261), we describe the number and type of TET2 mutations and examine their phenotypic and prognostic effects.