Key result
Arterial oxygen saturation at NICU admission shows 92% sensitivity for diagnosing infant CHD.
Why the study?
Infants with congenital heart disease present diverse clinical manifestations that make diagnosis difficult, and misdiagnosis leads to serious complications.
Do clinical symptoms and pulse oximetry accurately diagnose congenital heart disease in infants admitted to the NICU?
Cross-Sectional (n=150)
No
Do clinical symptoms and pulse oximetry accurately diagnose congenital heart disease in infants admitted to the NICU?
Clinical symptoms and pulse oximetry have high sensitivity for screening congenital heart disease in newborns admitted to the NICU, though their specificity is low.
Answers are grounded in this paper and cite their sources.
May support sensitive screening for congenital heart disease in NICU infants; leaves open need for prospective validation.
Background: Infants born with congenital heart disease (CHD) typically present different clinical manifestations which make this condition hard to diagnose. Considering serious complications arising from misdiagnosis, inventing new methods and/or improving traditional diagnostic approaches has always been a research objective. Methods: In this cross-sectional analysis, which took place in Children's Medical Center in Tehran, 150 infants admitted to an intensive care unit were evaluated based on echocardiographic findings from 2015 to 2017. Echocardiography was done due to abnormalities in physical examination and/or oxygen saturation level. Results: The sensitivity of clinical study value was 82% and the negative predictive value was 20%. The sensitivity of arterial oxygen saturation immediately after admission to the neonatal intensive care was 92%, the specificity was 34%, positive predictive value was 56% and negative predictive value was 25%. Conclusion: In terms of high sensitivity, clinical symptom including tachypnea, cyanosis, arrhythmias, respiratory distress, cardiac murmur, or arterial oxygen saturation level in newborns may be useful for screening CHD. Among the clinical manifestations, cyanosis and respiratory distress are more valuable.
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Zamani et al. (2020) conducted a cross-sectional in Congenital Heart Disease (CHD) (n=150). Clinical symptoms and pulse oximetry vs. Echocardiography (gold standard) was evaluated on Sensitivity of arterial oxygen saturation for diagnosing CHD. Arterial oxygen saturation immediately after admission to the neonatal intensive care unit demonstrated a sensitivity of 92% and specificity of 34% for diagnosing congenital heart disease in infants.
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