Key result
Noninvasive optical measures of cerebrovascular health are negatively correlated with age and positively correlated with cardiorespiratory fitness and gray and white matter volumes.
Why the study?
Do noninvasive optical measures of cerebrovascular health correlate with age, cardiorespiratory fitness, and brain volumes in older adults?
Observational
Do noninvasive optical measures of cerebrovascular health correlate with age, cardiorespiratory fitness, and brain volumes in older adults?
Noninvasive optical mapping of cerebral arterial pulse parameters provides valuable surrogate markers for cerebrovascular health that correlate with age, fitness, and cognitive function.
Optical cerebrovascular measures may serve as accessible surrogates in older adults; hypothesis-generating pending longitudinal validation.
Cerebrovascular support is crucial for healthy cognitive and brain aging. Arterial stiffening is a cause of reduced brain blood flow, a predictor of cognitive decline, and a risk factor for cerebrovascular accidents and Alzheimer's disease. Arterial health is influenced by lifestyle factors, such as cardiorespiratory fitness (CRF). We investigated new noninvasive optical measures of cerebrovascular health, which provide estimates of arterial pulse parameters (pulse pressure, transit time, and compliance/elasticity) within specific cerebral arteries and cortical regions, and low-resolution maps of large superficial cerebral arteries. We studied naturally occurring variability in these parameters in adults (aged 55-87), and found that these indices of cerebrovascular health are negatively correlated with age and positively with CRF and gray and white matter volumes. Further, regional pulse transit time predicts specific neuropsychological performance.
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Fabiani et al. (2014) conducted an observational in Cerebrovascular health. Noninvasive optical measures was evaluated on Correlation of arterial pulse parameters with age, cardiorespiratory fitness, and brain volumes. Noninvasive optical measures of cerebrovascular health are negatively correlated with age and positively correlated with cardiorespiratory fitness and gray and white matter volumes.
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