Laboratory investigation demonstrates GRP78 facilitates host cell attachment for MERS-CoV and bat HKU9, highlighting cross-species transmission risks.
, the lineage C MERS-CoV and the lineage D bCoV-HKU9. The capacity of GRP78 to facilitate surface attachment of both a human coronavirus and a phylogenetically related bat coronavirus exemplifies the need for continuous surveillance of the evolution of animal coronaviruses to monitor their potential for human adaptations.
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Chu et al. (2018) studied this question.
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