Advanced Testicular Cancer: Update for Urologists

No AccessJournal of UrologyClinical Urology: Review Article1 Dec 1998ADVANCED TESTICULAR CANCER: UPDATE FOR UROLOGISTS LAWRENCE H. EINHORN and JOHN P. DONOHUE LAWRENCE H. EINHORNLAWRENCE H. EINHORN More articles by this author and JOHN P. DONOHUEJOHN P. DONOHUE More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)62213-4AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Testicular cancer is a model for a curable neoplasm. We review past and present accomplishments in treating testis cancer and emphasize controversial surgical issues of interest to the urologist. Materials and Methods: We reviewed early and recent chemotherapy trials of germ cell tumors, stressing random prospective phase III studies. In addition, we address specific and complicated issues that are of particular relevance for the urologist, analyzing recently published articles. Results: Cisplatin combination chemotherapy has dramatically improved the cure rate for patients with germ cell tumors. The indications for post-chemotherapy resection for residual masses are discussed. Conclusions: The major goal 25 years ago was to develop a successful chemotherapy regimen for disseminated disease, which has now been accomplished with cisplatin combination chemotherapy. Present issues include optimal treatment in patients with poor prognostic characteristics, salvage chemotherapy strategies and indications for post-chemotherapy surgical resection. References 1 : Testicular cancer as a model for a curable neoplasm. The Richard and Hinda Rosenthal Foundation Award Lecture. Cancer Res.1981; 41: 3275. Google Scholar 2 : Treatment of testicular cancer: a new and improved model. J. Clin. Oncol.1990; 8: 1777. Google Scholar 3 : Surgical treatment of adult germinal testis tumors. Sem. Oncol.1979; 6: 55. 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Crossref, Medline, Google Scholar From the Indiana University Medical Center, Indianapolis, Indiana© 1998 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byJohnston P, Beck S, Cheng L, Masterson T, Bihrle R, Kesler K and Foster R (2013) Incidence, Histology and Management of Intraluminal Thrombus at Post-Chemotherapy Retroperitoneal Lymph Node DissectionJournal of Urology, VOL. 190, NO. 3, (874-877), Online publication date: 1-Sep-2013.DIECKMANN K, ALBERS P, CLASSEN J, DE WIT M, PICHLMEIER U, RICK O, MÜLLERLEILE U and KUCZYK M (2018) LATE RELAPSE OF TESTICULAR GERM CELL NEOPLASMS: A DESCRIPTIVE ANALYSIS OF 122 CASESJournal of Urology, VOL. 173, NO. 3, (824-829), Online publication date: 1-Mar-2005. Volume 160Issue 6 Part 1December 1998Page: 1964-1969 Advertisement Copyright & Permissions© 1998 by American Urological Association, Inc.MetricsAuthor Information LAWRENCE H. EINHORN More articles by this author JOHN P. 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