Key result
Analytical Windkessel method predicts ICA and ECA flow split with ~4% error versus clinical data.
Why the study?
CFD reliability depends on boundary condition accuracy, but clinical data beyond arterial geometry and inflow rate are rarely accessible, requiring a tool to estimate parameters like arterial resistance and compliance.
This analytical framework provides a method to estimate Windkessel parameters for distal branches of the carotid artery based on geometry, potentially reducing the time and computational cost required for accurate computational fluid dynamics simulations.
May streamline carotid CFD modeling; leaves open clinical translation pending validation.
Stroke occur mainly due to arterial thrombosis and rupture of cerebral blood vessels. Previous studies showed that blood flow-induced wall shear stress is an essential bio marker for estimating atherogenesis. It is a common practice to use computational fluid dynamics (CFD) simulations to calculate wall shear stress and to quantify blood flow. Reliability of predicted CFD results greatly depends on the accuracy of applied boundary conditions. Previously, the boundary conditions were estimated by varying values so that they matched the clinical data. It is applicable upon the availability of clinical data. Meanwhile, in most cases all that can be accessed are arterial geometry and inflow rate. Consequently, there is a need to devise a tool to estimate boundary values such as resistance and compliance of arteries. This study proposes an analytical framework to estimate the boundary conditions for a carotid artery based on the geometries of the downstream arteries available from clinical images.
No takes yet. Share an insight, caveat, or question.
Kizhisseri et al. (2023) studied Carotid artery blood flow. Analytical method for estimating Windkessel parameters vs. Clinical data (PCMRI and literature) was evaluated on Blood volume flow rate split between ICA and ECA. An analytical method for estimating Windkessel parameters accurately predicted the blood volume flow rate split between the internal and external carotid arteries with less than 4% error compared to clinical data.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: