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OBJECTIVE: Firefighters display elevated risk for diagnoses of mental health illnesses. Psychedelic-assisted therapies show promise in the treatment of clinically challenging conditions. This observational case series analyzed data from firefighters with mental health diagnoses who participated in a 12-week ketamine-assisted group therapy treatment plan. METHODS: Questionnaire scores (Generalized Anxiety Disorder Assessment-7, Patient Health Questionnaire-9, The Posttraumatic Stress Disorder Checklist -5, Brief Inventory of Psychosocial Functioning ) collected throughout the program were scored and statistically analyzed for changes. Qualitative data were analyzed through thematic analysis. RESULTS: Significant decreases with large effect sizes were detected in Generalized Anxiety Disorder Assessment-7 and The Posttraumatic Stress Disorder Checklist-5 scores after completion in the 12-week treatment plan, which persisted 6 months later. Participants noted it was beneficial being in a cohort with fellow firefighters. CONCLUSIONS: Statistically and clinically significant improvements to posttraumatic stress disorder and anxiety diagnoses were detected in the cohort of firefighters after the Roots to Thrive Ketamine-Assisted Group Therapy program, with results retained six months post treatment.
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Tsang et al. (2025) studied this question.
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