Key result
In patients receiving warfarin, 5-fluorouracil resulted in a similar mean change in INR compared to capecitabine (4.62 vs 5.11, p=0.87) over 90 days.
Why the study?
Does 5-fluorouracil compared to capecitabine cause a different change in INR in patients receiving therapeutic doses of warfarin?
Cohort (n=24)
Does 5-fluorouracil compared to capecitabine cause a different change in INR in patients receiving therapeutic doses of warfarin?
There is no significant difference in INR elevation or bleeding events when comparing the drug interactions of 5-fluorouracil-warfarin and capecitabine-warfarin.
Similar INR changes observed with both agents; leaves open whether interactions are equivalent in randomized settings.
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Shah et al. (2010) conducted a cohort in Patients receiving therapeutic doses of warfarin and a fluoropyrimidine (n=24). 5-fluorouracil vs. capecitabine was evaluated on mean change in international normalized ratio (INR) from baseline to end of 90-day study period (p=0.87). In patients receiving warfarin, 5-fluorouracil resulted in a similar mean change in INR compared to capecitabine (4.62 vs 5.11, p=0.87) over 90 days.
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