Key result
Higher sleep glucose links to moderately lower HRV, reflecting autonomic nervous system activity.
Why the study?
This study investigated whether glucose fluctuations during sleep could serve as a measure of stress by examining their relationship with heart rate variability in healthy subjects.
Do glucose fluctuations correlate with heart rate variability during sleep in healthy subjects?
Cross-Sectional (n=5)
Do glucose fluctuations correlate with heart rate variability during sleep in healthy subjects?
Effect estimate: r = -0.453
Glucose fluctuations during sleep show a moderate negative correlation with heart rate variability, suggesting potential utility as a marker of autonomic nervous system activity.
Hypothesis-generating for nocturnal glucose as autonomic marker; leaves open validation in larger or clinical cohorts.
OBJECTIVE: The body's glucose concentration is influenced by carbohydrate intake, insulin-induced carbohydrate reduction, and hepatic glycogen breakdown induced by stress hormones. This study investigated the potential of employing glucose fluctuations as a measure of stress by examining the relationship between heart rate variability (HRV) data and glucose levels during sleep in healthy subjects. METHODS: In this cross-sectional study, a chest-worn electrocardiogram (ECG) and continuous glucose monitoring device (CGM) were respectively used to monitor the heart rate intervals and glucose fluctuations of five subjects (two males, three females) during sleep. A time-series correlation analysis was performed on the HRV data extracted from heart rate intervals and the corresponding glucose fluctuation data. RESULTS: The time-series analysis of ECG and CGM data collected from subjects during sleep (n = 25 nights) revealed a moderate negative correlation between glucose levels and HRV, with a cross-correlation coefficient of r = -0.453. CONCLUSION: Similar to HRV, changes in stress levels can be detected by observing glucose fluctuations, particularly during sleep when the impact of food intake can be eliminated. Our findings highlight a significant correlation between glucose levels and HRV, indicating that glucose fluctuations can be used as an indicator of autonomic nervous system activity in an exploratory study.
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Kajisa et al. (2023) conducted a cross-sectional in Healthy subjects (n=5). Continuous glucose monitoring and electrocardiogram was evaluated on Correlation between glucose levels and heart rate variability (r = -0.453). Glucose levels during sleep demonstrated a moderate negative correlation with heart rate variability (r = -0.453), indicating glucose fluctuations may reflect autonomic nervous system activity.
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