What does this research mean for the field?

Reduced insulin sensitivity is associated with a blunted postprandial sympathetic nervous system response and decreased thermic effect of food. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 2006The Journal of Medical InvestigationOpen Access

Relationships between thermic effect of food, insulin resistance and autonomic nervous activity

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Why the study?

Does insulin resistance correlate with the thermic effect of food and postprandial autonomic nervous activity in healthy young adults?

Structured PICO

Does insulin resistance correlate with the thermic effect of food and postprandial autonomic nervous activity in healthy young adults?

Population

20 healthy young adults (9 men, 11 women; mean age 21.3±2.3 years), weight stable, untrained, nonsmokers. Excluded: obesity (BMI >25.0), hypertension, diabetes mellitus, and recent use of autonomic nervous drugs.

Intervention

Standardized solid meal (600 Kcal; 55% carbohydrates, 30% fat, 15% protein)

Comparator

Pre-meal fasting/resting state

Outcome

Relationships between thermic effect of food (TEF), insulin resistance (HOMA-IR), and autonomic nervous activity (LF/HF ratio via heart rate variability) measured from 1 hour before to 2 hours after a mealsurrogate

Reduced insulin sensitivity is associated with a blunted postprandial sympathetic nervous system response and a decreased thermic effect of food, potentially contributing to energy storage and obesity.

Limitations

Estrous cycle of female subjects was not measured or controlled for
Subjects were not severely insulin resistant (lacked subjects with HOMA-IR > 2.5)

Discussion

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Implication

May link insulin resistance to blunted postprandial thermogenesis in youth; leaves open causal role in obesity.

Cite This Study

Watanabe et al. (2006) studied this question.

synapsesocial.com/papers/6a186f4525af1eb19ec9a427 https://doi.org/10.2152/jmi.53.153

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Relationships between thermic effect of food, insulin resistance and autonomic nervous activity

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Relationships between thermic effect of food, insulin resistance and autonomic nervous activity

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

Also Consider