Key result
En bloc excision and chemoradiation treat a 13-year-old's synovial sarcoma mimicking benign lower extremity swelling.
Why the study?
Monophasic synovial sarcoma is a rare, aggressive soft-tissue malignancy that often resembles benign conditions, making diagnosis challenging.
Case Report (n=1)
Highlights the importance of maintaining a high index of suspicion for malignancy in deep-seated soft-tissue tumors that may mimic benign pathology.
Warrants vigilance for malignancy in pediatric soft-tissue masses mimicking benign lesions; leaves open optimal multimodal therapy for monophasic synovial sarcoma.
Monophasic synovial sarcoma (SS) is a rare and aggressive soft-tissue malignancy that can often resemble benign conditions, making diagnosis challenging. A 13-year-old girl presented with a painless, gradually enlarging swelling in the proximal lower extremity for 4 months. Clinical examination revealed a firm, well-defined, deep-seated swelling, and imaging initially indicated a benign spindle-cell tumor, likely a schwannoma. En bloc excision of the mass was done. Histopathology and immunohistochemistry (positive for TLE1 and BCL2) revealed the diagnosis of monophasic SS. Adjuvant chemotherapy and radiotherapy were given. This case highlights the importance of maintaining a high index of suspicion for malignancy in deep-seated soft-tissue tumors. Early diagnosis, complete surgical removal, and multimodal therapy are crucial for the management of SS.
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Singh et al. (2025) conducted a case report in Monophasic synovial sarcoma (n=1). En bloc excision, adjuvant chemotherapy, and radiotherapy was evaluated. En bloc excision, chemotherapy, and radiotherapy were utilized to treat a 13-year-old girl with monophasic synovial sarcoma that initially presented as a benign-appearing lower extremity swelling.
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