Evolution of antithrombotic therapy for patients with atrial fibrillation: The prospective global GLORIA-AF registry program

Figures

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  Fig 1. Factors most strongly associated with prescription of no OAC treatment (AP only and no treatment) versus OAC therapy (NOAC and VKA) in phase II (A) and phase III (B). AF, atrial fibrillation; BMI, body mass index; CHA2DS2−VASc (congestive heart failure, hypertension, age ≥75 years, diabetes, stroke/transient ischemic attack/systemic embolism, vascular disease, age from 65–74 years, sex category [female]); CI, confidence interval; F, female; HAS-BLED (hypertension, abnormal renal/liver function, stroke, bleeding history or predisposition, labile international normalized ratio, elderly [>65 years], drugs or alcohol concomitantly); M, male; NOAC, novel/nonvitamin K oral anticoagulants; OAC, oral anticoagulation; ref, reference; RR, relative risk; TIA, transient ischemic attack; VKA, vitamin K antagonist. *Effect estimates obtained from the model including all variables of interest and the risk scores, but not the components of the risk scores.

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  Fig 2. Factors most strongly associated with prescription of NOAC versus VKA in phase II (A) and phase III (B). AF, atrial fibrillation; CHA2DS2−VASc (congestive heart failure, hypertension, age ≥75 years, diabetes, stroke/transient ischemic attack/systemic embolism, vascular disease, age from 65–74 years, sex category [female]); CI, confidence interval; F, female; GP, general practitioner; HAS-BLED (hypertension, abnormal renal/liver function, stroke, bleeding history or predisposition, labile international normalized ratio, elderly [>65 years], drugs or alcohol concomitantly); M, male; NOAC, novel/nonvitamin K oral anticoagulants; PCP, primary care physician; ref, reference; RR, relative risk; TIA, transient ischemic attack; VKA, vitamin K antagonist. *Effect estimates obtained from the model including all variables of interest and the risk scores, but not the components of the risk scores.

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  Fig 3. Factors most strongly associated with prescription of AP only versus no ATT in phase II (A) and phase III (B). AP, antiplatelet; ATT, antithrombotic treatment; CHA2DS2−VASc (congestive heart failure, hypertension, age ≥75 years, diabetes, stroke/transient ischemic attack/systemic embolism, vascular disease, age from 65–74 years, sex category [female]); CI, confidence interval; F, female; GP, general practitioner; HAS-BLED (hypertension, abnormal renal/liver function, stroke, bleeding history or predisposition, labile international normalized ratio, elderly [>65 years], drugs or alcohol concomitantly); M, male; PCP, primary care physician; ref, reference; RR, relative risk. *Effect estimates obtained from the model including all variables of interest and the risk scores, but not the components of the risk scores.

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  Fig 4. Analysis of ATT pattern in phase III by countries. AP, antiplatelet; ARG, Argentina; ATT, antithrombotic treatment; AUT, Austria; BEL, Belgium; BGR, Bulgaria; BRA, Brazil; CAN, Canada; CHE, Switzerland; CHL, Chile; CHN, China; COL, Colombia; CZE, Czech Republic; DNK, Denmark; DEU, Germany; ECU, Ecuador; ESP, Spain; EST, Estonia; FRA, France; GBR, United Kingdom of Great Britain and Northern Ireland; GRC, Greece; HKG, Hong Kong; HRV, Croatia; IRL, Ireland; ITA, Italy; JPN, Japan; KOR, Korea; LVA, Latvia; MEX, Mexico; NLD, the Netherlands; NOAC, novel/nonvitamin K oral anticoagulants; NOR, Norway; PER, Peru; POL, Poland; PRT, Portugal; ROU, Romania; RUS, Russian Federation; SGP, Singapore; SVN, Slovenia; TWN, Taiwan; USA, United States of America; VKA, vitamin K antagonist.