Why the study?
Limited research has investigated left ventricular mechanical dispersion following myocardial infarction, prompting this study to assess its prognostic value and correlation with myocardial scar heterogeneity.
Does CMR-derived left ventricular mechanical dispersion (LVMD) predict the composite of sudden cardiac death, sustained ventricular arrhythmias, and new-onset heart failure in post-myocardial infarction patients?
Population
181 post-MI patients undergoing CMR
Comparison
CMR-derived LVMD and border zone entropy for adverse clinical outcomes
Design
Observational cohort study
Follow-up
Median 31 months
Key result
Cardiac magnetic resonance-derived left ventricular mechanical dispersion independently predicted the primary composite endpoint of sudden cardiac death, sustained ventricular arrhythmias, and new-onset heart failure in post-myocardial infarction patients (HR 1.014).
Authors
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Hypothesis-generating for CMR-derived LVMD in post-MI risk stratification; prospective trials needed before clinical adoption.
Cohort (n=181)
No
Does CMR-derived left ventricular mechanical dispersion (LVMD) predict the composite of sudden cardiac death, sustained ventricular arrhythmias, and new-onset heart failure in post-myocardial infarction patients?
Effect estimate: HR 1.014 (95% CI 1.003-1.024)
p-value: p=0.010
CMR-derived left ventricular mechanical dispersion and border zone entropy are independent predictors of adverse outcomes after myocardial infarction, improving risk stratification beyond LVEF alone.
Zhao et al. (2025) conducted a cohort in Myocardial Infarction (n=181). Cardiac magnetic resonance-derived left ventricular mechanical dispersion (LVMD) was evaluated on Composite of sudden cardiac death, sustained ventricular arrhythmias or/and ICD implantation, and new-onset heart failure (HR 1.014, 95% CI 1.003-1.024, p=0.010). Cardiac magnetic resonance-derived left ventricular mechanical dispersion independently predicted the primary composite endpoint of sudden cardiac death, sustained ventricular arrhythmias, and new-onset heart failure in post-myocardial infarction patients (HR 1.014).