Key result
Myocardial stunning in canine and rat models is associated with increased phosphorylation of cardiac myosin binding protein C, which is inhibited when stunning is prevented.
Why the study?
Does myocardial stunning alter the phosphorylation of cardiac myosin binding protein C in canine and rat models?
Population
Canine regional myocardial stunning model and rat global myocardial stunning model
Comparison
Ischemia and reperfusion (myocardial stunning) vs Ischemic preconditioning or reperfusion in…
Design
Preclinical
Authors
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May implicate cMyBP-C phosphorylation in transient post-ischemic dysfunction; leaves open translation to human stunning and interventions.
Does myocardial stunning alter the phosphorylation of cardiac myosin binding protein C in canine and rat models?
Myocardial stunning induces specific phosphorylation changes in cardiac myosin binding protein C, suggesting a mechanistic role in transient contractile dysfunction.
Yuan et al. (2006) studied Myocardial stunning. Ischemic preconditioning or reperfusion in low-calcium buffer vs. Stunning without prevention was evaluated on Phosphorylation of cardiac myosin binding protein C (cMyBP-C). Myocardial stunning in canine and rat models is associated with increased phosphorylation of cardiac myosin binding protein C, which is inhibited when stunning is prevented.
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