Key result
Adolescent type 1 diabetes is linked to higher colonic motility and pressure despite normal transit times.
Why the study?
The study was conducted to assess the prevalence of objective signs of gastrointestinal autonomic neuropathy in adolescents with type 1 diabetes and investigate associations with self-reported symptoms or other autonomic neuropathy findings.
Are there objective signs of gastrointestinal autonomic neuropathy assessed by wireless motility capsules in adolescents with type 1 diabetes compared to healthy controls?
Cross-Sectional (n=70)
Are there objective signs of gastrointestinal autonomic neuropathy assessed by wireless motility capsules in adolescents with type 1 diabetes compared to healthy controls?
p-value: p=<0.05
Objective signs of gastrointestinal neuropathy, such as altered colonic motility, are common in adolescents with type 1 diabetes and correlate with gastrointestinal symptoms and glycemic control.
May signal early colonic dysmotility in T1D adolescents; hypothesis-generating for neuropathy screening pending longitudinal data.
Background: To assess the prevalence of objective signs of gastrointestinal (GI) autonomic neuropathy (AN) in adolescents with type 1 diabetes (T1D). In addition, to investigate associations between objective GI findings and self-reported symptoms or other findings of AN. Methods: Fifty adolescents with T1D and 20 healthy adolescents were examined with a wireless motility capsule to assess the total and regional GI transit times and motility index. GI symptoms were evaluated with the GI Symptom Rating Scale questionnaire. AN was evaluated with cardiovascular and quantitative sudomotor axon reflex tests. Results: There was no difference in GI transit times in adolescents with T1D and healthy controls. Adolescents with T1D had a higher colonic motility index and peak pressure than the controls, and GI symptoms were associated with low gastric and colonic motility index (all p < 0.05). Abnormal gastric motility was associated with the duration of T1D, while a low colonic motility index was inversely associated with “time in target range” for blood glucose (all p < 0.01). No associations were found between signs of GI neuropathy and other measures of AN. Conclusions: Objective signs of GI neuropathy are common in adolescents with T1D and it seems to require early interventions in patients at high risk of developing GI neuropathy.
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Rasmussen et al. (2023) conducted a cross-sectional in Type 1 diabetes (n=70). Wireless motility capsule assessment vs. Healthy adolescents was evaluated on Total and regional gastrointestinal transit times and motility index (p=<0.05). Adolescents with type 1 diabetes demonstrated a higher colonic motility index and peak pressure compared to healthy controls (p<0.05), despite no difference in gastrointestinal transit times.
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