Key result
Apixaban's main degradation pathways under stress conditions were established using liquid chromatography coupled to multistage high-resolution mass spectrometry.
This study establishes the degradation pathways of apixaban under stress conditions using advanced mass spectrometry techniques.
Apixaban degradation pathways now mapped analytically; leaves open any impact on formulation stability or clinical handling.
The main degradation pathways of apixaban, a novel anticoagulant drug acting as factor Xa inhibitor, has been established based on the degradation products identification using liquid chromatography coupled to multistage high resolution mass spectrometry.
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Secrétan et al. (2015) studied this question. Apixaban's main degradation pathways under stress conditions were established using liquid chromatography coupled to multistage high-resolution mass spectrometry.
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