Key result
Angiopoietin-like proteins (ANGPTL1-8) exhibit pleiotropic effects, playing key functional roles in lipid and glucose metabolism, angiogenesis, inflammation, and cancer.
This review highlights the diverse physiological and pathophysiological roles of the eight angiopoietin-like proteins, particularly their emerging potential as therapeutic targets for cardio-metabolic diseases.
Angiopoietin-like proteins (ANGPTLs) are a family of proteins structurally similar to the angiopoietins. To date, eight ANGPTLs have been discovered, namely ANGPTL1 to ANGPTL8. Emerging evidence implies a key role for ANGPTLs in the regulation of a plethora of physiological and pathophysiological processes. Most of the ANGPTLs exhibit multibiological properties, including established functional roles in lipid and glucose metabolism, inflammation, hematopoiesis, and cancer. This report represents a systematic and updated appraisal of this class of proteins, focusing on the main features of each ANGPTL.
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Gaetano Santulli (2014) conducted a review in Metabolic diseases, cardiovascular diseases, and cancer. Angiopoietin-like proteins (ANGPTLs) was evaluated. Angiopoietin-like proteins (ANGPTL1-8) exhibit pleiotropic effects, playing key functional roles in lipid and glucose metabolism, angiogenesis, inflammation, and cancer.
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