Key result
Sunitinib and sorafenib caused distinct myocardial and mitochondrial toxicities in rat models, whereas pazopanib did not, suggesting cardiotoxicity is not a classwide effect of VEGFR inhibition.
Why the study?
Do sunitinib, sorafenib, and pazopanib have different cardiotoxic effects on myocardial function and structure in rat models?
Population
Rat model concurrently exposed to the cardiac stressor dobutamine, and neonatal rat cardiomyocyte cultures
Design
Preclinical
Authors
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Supports differential VEGFR TKI cardiotoxicity in rats; leaves open human translation and off-target mechanisms.
Do sunitinib, sorafenib, and pazopanib have different cardiotoxic effects on myocardial function and structure in rat models?
Cardiotoxicity of multikinase angiogenesis inhibitors is not a class-wide effect of VEGFR inhibition and may instead be driven by off-target kinase inhibition leading to mitochondrial toxicity.
French et al. (2010) studied Cardiotoxicity. Sunitinib, sorafenib, and pazopanib was evaluated on Myocardial function and structure. Sunitinib and sorafenib caused distinct myocardial and mitochondrial toxicities in rat models, whereas pazopanib did not, suggesting cardiotoxicity is not a classwide effect of VEGFR inhibition.
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