What does this research mean for the field?

Intracoronary injection of basic fibroblast growth factor (bFGF) reduces infarct size and improves cardiac systolic function by stimulating angiogenesis in infarcted myocardium. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 4, 1992Science

Salvage of Infarcted Myocardium by Angiogenic Action of Basic Fibroblast Growth Factor

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Why the study?

Does intracoronary injection of basic fibroblast growth factor (bFGF) improve cardiac systolic function and reduce infarct size in a canine experimental myocardial infarct model?

Population

canine experimental myocardial infarct model

Design

Preclinical

Authors

AYAtsuko Yanagisawa‐MiwaThe University of Tokyo YUYasumi UchidaTsukuba Memorial Hospital FNFumitaka NakamuraBunkyo University

Discussion

Member takes

Implication

Hypothesis-generating for intracoronary bFGF post-MI; human trials required before clinical consideration.

Structured PICO

Does intracoronary injection of basic fibroblast growth factor (bFGF) improve cardiac systolic function and reduce infarct size in a canine experimental myocardial infarct model?

Population

canine experimental myocardial infarct model

Intervention

intracoronary injection of basic fibroblast growth factor (bFGF)

Outcome

cardiac systolic function and infarct sizesurrogate

Intracoronary injection of bFGF promotes angiogenesis, reduces infarct size, and improves systolic function in a canine model of myocardial infarction.

Cite This Study

Yanagisawa‐Miwa et al. (1992) studied this question.

synapsesocial.com/papers/6a18e1dfa09e0bfd307c122e https://doi.org/10.1126/science.1382313

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