Transition-Metal-Catalyzed Borylation of Organic Halides with Hydroboranes

Metal-catalyzed cross-coupling reaction of B-H compounds provides a direct method for conversion of C-X bonds to C-B bonds.Dialkoxyboranes are excellent boron sources in the borylation of aryl, 1-alkenyl, allyl or benzyl halides or pseudohalides.These reactions tolerate large number of functional groups and proceeds with excellent yields, thereby allowing the simple, convenient, and elegant preparation of functionalized C-B compounds.CONTENTS 1. Introduction 2. Borylation of Aryl Electrophiles 2-1.Reaction Conditions 2-1-1.Electrophiles and Catalysts 2-1-1-1.Aryl Iodides and Perfluoroalkanesulfonates 2-1-1-2.Electron-Rich Aryl Bromides 2-1-1-3.Electron-Deficient Aryl Bromides and Aryl Chlorides 2-1-1-4.Aryl Arenesulfonates 2-1-1-5.Other Catalyst Systems 2-1-2.Hydroboranes 2-1-2-1.4,4,6-Trimethyl-1,3,2-dioxaborinane 2-1-2-2.5,5-Dimethyl-1,3,2-dioxaborinane 2-2.Catalytic Cycle 2-3.Synthesis of Arylboronates 3.