HIV infection in men was strongly associated with higher triglycerides (+76%, 95% CI: 53 to 103) and lower HDL-C, with greater visceral and less leg subcutaneous adipose tissue driving this risk.
Observational (n=882)
How do regional adipose tissue depots and HIV infection associate with fasting lipid levels in men?
In HIV-infected men, reduced leg subcutaneous adipose tissue and increased visceral adipose tissue are associated with a proatherogenic dyslipidemia profile characterized by high triglycerides and low HDL-C.
Effect estimate: +76% (95% CI 53 to 103)
Absolute Event Rate: 170% vs 107%
p-value: p=< 0.0001
BACKGROUND: HIV infection and antiretroviral therapy are associated with dyslipidemia, but the association between regional adipose tissue depots and lipid levels is not defined. METHODS: The association of magnetic resonance imaging-measured visceral adipose tissue (VAT) and regional subcutaneous adipose tissue (SAT) volume with fasting lipid parameters was analyzed by multivariable linear regression in 737 HIV-infected and 145 control men from the study of Fat Redistribution and Metabolic Change in HIV Infection. RESULTS: HIV-infected men had higher median triglycerides (170 mg/dL vs. 107 mg/dL; P < 0.0001), lower high-density lipoprotein cholesterol (HDL-C; 38 mg/dL vs. 46 mg/dL; P < 0.0001), and lower low-density lipoprotein cholesterol (LDL-C; 105 mg/dL vs. 125 mg/dL; P < 0.0001) than controls. After adjustment, greater VAT was associated with higher triglycerides and lower HDL-C in HIV-infected and control men, whereas greater leg SAT was associated with lower triglycerides in HIV-infected men with a similar trend in controls. More upper trunk SAT was associated with higher LDL-C and lower HDL-C in controls, whereas more lower trunk SAT was associated with higher triglycerides in controls. After adjustment, HIV infection remained strongly associated (P < 0.0001) with higher triglycerides (+76%, 95% confidence interval CI: 53 to 103), lower LDL-C (-19%, 95% CI: -25 to -12), and lower HDL-C (-18%, 95% CI: -22 to -12). CONCLUSIONS: HIV-infected men are more likely than controls to have higher triglycerides and lower HDL-C, which promote atherosclerosis, but also lower LDL-C. Less leg SAT and more VAT are important factors associated with high triglycerides and low HDL-C in HIV-infected men. The reduced leg SAT in HIV-infected men with lipoatrophy places them at increased risk for proatherogenic dyslipidemia.
Wohl et al. (Fri,) conducted a observational in HIV infection and dyslipidemia (n=882). HIV infection and regional adipose tissue vs. Healthy controls was evaluated on Fasting triglycerides (mg/dL) (+76%, 95% CI 53 to 103, p=< 0.0001). HIV infection in men was strongly associated with higher triglycerides (+76%, 95% CI: 53 to 103) and lower HDL-C, with greater visceral and less leg subcutaneous adipose tissue driving this risk.