Acute 60-minute exposure to high or very high hypoxia prior to an oral glucose tolerance test did not affect peak plasma glucose concentration (7.7 vs 7.5 mmol/L; p=0.777) in males with overweight.
Does acute hypoxia exposure prior to an OGTT improve glucose homeostasis in males with overweight?
Acute exposure to high or very high hypoxia prior to an OGTT does not improve glucose homeostasis in males with overweight and is associated with adverse symptoms at very high levels.
Tasa de eventos absoluta: 7.7% vs 7.5%
valor p: p=0.777
Abstract Previous research has shown that ≤60 min hypoxic exposure improves subsequent glycaemic control, but the optimal level of hypoxia is unknown and data are lacking from individuals with overweight. We undertook a cross‐over pilot feasibility study investigating the effect of 60‐min prior resting exposure to different inspired oxygen fractions (CON F I O 2 = 0.209; HIGH F I O 2 = 0.155; VHIGH F I O 2 = 0.125) on glycaemic control, insulin sensitivity, and oxidative stress during a subsequent oral glucose tolerance test (OGTT) in males with overweight (mean (SD) BMI = 27.6 (1.3) kg/m 2 ; n = 12). Feasibility was defined by exceeding predefined withdrawal criteria for peripheral blood oxygen saturation (SpO 2 ), partial pressure of end‐tidal oxygen or carbon dioxide and acute mountain sickness (AMS), and dyspnoea symptomology. Hypoxia reduced SpO 2 in a stepwise manner (CON = 97(1)%; HIGH = 91(1)%; VHIGH = 81(3)%, p 0.05). We observed no between‐conditions differences in oxidative stress ( p > 0.05), but dyspnoea and AMS symptoms increased in VHIGH ( p < 0.05), with one participant meeting the withdrawal criteria. Acute HIGH or VHIGH exposure prior to an OGTT does not influence glucose homeostasis in males with overweight, but VHIGH is associated with adverse symptomology and reduced feasibility.
Corbett et al. (Mon,) conducted a other in Overweight (n=12). Acute hypoxia (HIGH FIO2 = 0.155 or VHIGH FIO2 = 0.125) vs. Normoxia (CON FIO2 = 0.209) was evaluated on Peak plasma glucose concentration during subsequent oral glucose tolerance test (p=0.777). Acute 60-minute exposure to high or very high hypoxia prior to an oral glucose tolerance test did not affect peak plasma glucose concentration (7.7 vs 7.5 mmol/L; p=0.777) in males with overweight.