J. O. Irwin, E. A. Cheeseman, On the Maximum-Likelihood Method of Determining Dosage-Response Curves and Approximations to the Median-Effective Dose, in Cases of a Quantal Response, Supplement to the Journal of the Royal Statistical Society, Vol. 6, No. 2 (1939), pp. 174-185
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Irwin et al. (1939) studied this question.
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