Co-administration of Quercetin and NLRP3 Inhibitor Attenuates Inflammation and Oxidative Stress in Cuprizone-Induced Demyelination Model

Farhad Nourmohammadi; Amirreza Javan; Moein Shirzad; Farzin Sadeghi; Maryam Ghasemi‐Kasman

doi:10.1016/j.brainresbull.2026.111967

May 1, 2026Brain Research BulletinOpen Access

Co-administration of Quercetin and NLRP3 Inhibitor Attenuates Inflammation and Oxidative Stress in Cuprizone-Induced Demyelination Model

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Key Points

The study aims to assess the effectiveness of quercetin and MCC950 in reducing demyelination and inflammation.
In vivo model of demyelination induced by cuprizone was utilized.
Intervention involved co-administration of quercetin and NLRP3 inhibitor MCC950.
Assessment of inflammation and oxidative stress levels in the corpus callosum was performed.
Co-administration of quercetin and MCC950 significantly ameliorated demyelination in the corpus callosum.
Marked reduction in astrocytes activation was observed with treatment.
Oxidative stress and inflammation levels were significantly lower in the treated group.

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Implication

Shows that co-administration of quercetin and MCC950 reduces inflammation in a demyelination model, indicating a potential therapeutic approach.

Abstract

• Co-administration of quercetin and MCC950 ameliorates demyelination in the corpus callosum. • Co-administration of quercetin and MCC950 attenuates astrocytes activation in the corpus callosum. • Co-administration of quercetin and MCC950 reduces oxidative stress and inflammation in the corpus callosum.

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Nourmohammadi et al. (2026) studied this question.

synapsesocial.com/papers/6a192c8bfab5b468c44156f3 https://doi.org/10.1016/j.brainresbull.2026.111967

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Co-administration of Quercetin and NLRP3 Inhibitor Attenuates Inflammation and Oxidative Stress in Cuprizone-Induced Demyelination Model

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Co-administration of Quercetin and NLRP3 Inhibitor Attenuates Inflammation and Oxidative Stress in Cuprizone-Induced Demyelination Model

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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