Key result
AAA shows similar cancer incidence to CAD but is linked to ~54% worse overall survival.
Why the study?
Recent studies highlight the importance of cancer screening and high malignancy incidence in cardiovascular diseases, prompting comparison of cancer incidence and overall survival between patients with abdominal aortic aneurysm and coronary artery disease.
Does having an abdominal aortic aneurysm compared to coronary artery disease increase the long-term incidence of cancer and reduce overall survival?
Population
151 AAA patients and 539 CAD patients admitted to a university hospital in Belgium
Comparison
Patients with AAA vs patients with CAD
Design
Cohort study
Follow-up
15 years
Authors
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Suggests prolonged cancer surveillance may be considered in AAA; leaves open causality and need for prospective validation.
Cohort (n=690)
No
Does having an abdominal aortic aneurysm compared to coronary artery disease increase the long-term incidence of cancer and reduce overall survival?
Absolute Event Rate: 30% vs 28%
p-value: p=0.60
Patients with abdominal aortic aneurysm have a higher long-term risk of incident cancer and lower overall survival compared to patients with coronary artery disease, highlighting the potential need for enhanced cancer screening in this population.
Sakalihasan et al. (2026) conducted a cohort in Abdominal aortic aneurysm and coronary artery disease (n=690). Abdominal aortic aneurysm vs. Coronary artery disease was evaluated on Cumulative incidence rate of cancer (p=0.60). Patients with abdominal aortic aneurysm had similar 15-year cancer incidence compared to coronary artery disease patients (30% vs 28%, p=0.60) but worse overall survival (HR 1.54; 95% CI 1.22-1.94).