Resolution of the ABA Biosynthesis Controversy: Discovery of a Dihydroxylating Terpene Synthase and Its Convergent Evolution

Víctor Coca-Ruiz; Katharina Hausmann; Gerald Dräger; Henry Struwe; Maria Zahid; Josefina Aleu; Dörte Solle; Andreas Kirschning; Isidro G. Collado; Sascha Beutel

doi:10.1021/acschembio.6c00103

May 26, 2026ACS Chemical BiologyOpen Access

Resolution of the ABA Biosynthesis Controversy: Discovery of a Dihydroxylating Terpene Synthase and Its Convergent Evolution

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Key Points

The aim is to clarify the role of BcStc5 in ABA biosynthesis and evaluate its enzymatic function.
Characterization of BcStc5 enzyme activity through metabolic pathway analysis.
Production titers of over 550 mg/L were achieved in the experimental setup.
BcStc5 is confirmed to act as an eudesmanediol synthase instead of the previously attributed ABA cyclase.
This finding resolves a long-standing controversy regarding the biosynthesis of ABA.

Implication

Characterizes BcStc5 as an eudesmanediol synthase, resolving biosynthetic controversy.

Abstract

, achieving titers >550 mg/L. This work resolves a long-standing biosynthetic controversy, characterizing BcStc5 as an eudesmanediol synthase rather than the ABA cyclase, settling the controversy over this protein.

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Cite This Study

Coca-Ruiz et al. (2026) studied this question.

synapsesocial.com/papers/6a192cb4fab5b468c4415884 https://doi.org/10.1021/acschembio.6c00103

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Resolution of the ABA Biosynthesis Controversy: Discovery of a Dihydroxylating Terpene Synthase and Its Convergent Evolution

Key Points

Implication

Abstract

Discussion

Cite This Study

Resolution of the ABA Biosynthesis Controversy: Discovery of a Dihydroxylating Terpene Synthase and Its Convergent Evolution

Key Points

Implication

Abstract

Discussion

Cite This Study

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