What question did this study set out to answer?

The research aims to evaluate the obesogenic effects of various PFAS on adipogenesis and their interaction with PPARγ.

May 29, 2026Regulatory Toxicology and Pharmacology0 citationsOpen Access

Assessment of the obesogenic properties of PFAS using an in vitro-based testing strategy

SLSander B.I. LentzUtrecht University WBWieneke BilNational Institute for Public Health and the Environment BBBas BokkersNational Institute for Public Health and the Environment

Key Points

The research aims to evaluate the obesogenic effects of various PFAS on adipogenesis and their interaction with PPARγ.
Utilized in vitro testing to assess the impact of seven PFAS on adipogenesis.
Examined PPARγ transactivation as a potential mechanism for PFAS-induced adipogenesis.
Included notable PFAS such as HFPO-DA, FSBA, TFA, PFOS, and PFDA.
Seven PFAS, including HFPO-DA and FSBA, transactivated PPARγ and induced adipogenesis.
Some PFAS-induced adipogenesis was not linked to PPARγ transactivation.
PFAS like TFA, PFOS, and PFDA inhibited adipogenesis in vitro.

Abstract

• This study provides guidance on using NAMs to identify obesogens • Seven PFAS, including HFPO-DA and FSBA, transactivated PPARγ and induced adipogenesis • For some PFAS, induced adipogenesis was not correlated with PPARγ transactivation • Seven PFAS, among which TFA, PFOS, and PFDA, suppressed adipogenesis in vitro • Elaboration of the integrated testing strategy for obesity is needed

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